Application of a Deep Learning Approach to Analyze Large-Scale MRI Data of the Spine.

With its standardized MRI datasets of the entire spine, the German National Cohort (GNC) has the potential to deliver standardized biometric reference values for intervertebral discs (VD), vertebral bodies (VB) and spinal canal (SC). To handle such large-scale big data, artificial intelligence (AI) tools are needed. In this manuscript, we will present an AI software tool to analyze spine MRI and generate normative standard values. 330 representative GNC MRI datasets were randomly selected in equal distribution regarding parameters of age, sex and height. By using a 3D U-Net, an AI algorithm was trained, validated and tested. Finally, the machine learning algorithm explored the full dataset (n = 10,215). VB, VD and SC were successfully segmented and analyzed by using an AI-based algorithm. A software tool was developed to analyze spine-MRI and provide age, sex, and height-matched comparative biometric data. Using an AI algorithm, the reliable segmentation of MRI datasets of the entire spine from the GNC was possible and achieved an excellent agreement with manually segmented datasets. With the analysis of the total GNC MRI dataset with almost 30,000 subjects, it will be possible to generate real normative standard values in the future.

Regular expressions for decoding of neural network outputs.

This article proposes a convenient tool for decoding the output of neural networks trained by Connectionist Temporal Classification (CTC) for handwritten text recognition. We use regular expressions to describe the complex structures expected in the writing. The corresponding finite automata are employed to build a decoder. We analyze theoretically which calculations are relevant and which can be avoided. A great speed-up results from an approximation. We conclude that the approximation most likely fails if the regular expression does not match the ground truth which is not harmful for many applications since the low probability will be even underestimated. The proposed decoder is very efficient compared to other decoding methods. The variety of applications reaches from information retrieval to full text recognition. We refer to applications where we integrated the proposed decoder successfully.